| 2016-05-28 18:00:34May 28, 2016 |   Oakville Longhorns @ GTA All Stars | 16 - 34 | 2016 | Chinguacousy Park | Recap |
| 2016-05-28 19:00:06May 28, 2016 |   Steel City Patriots @ Ottawa Invaders | 22 - 27 | 2016 | Gee-Gees Stadium | Recap |
| 2016-05-28 19:00:18May 28, 2016 |   Tri-City Outlaws @ Sarnia Imperials | 30 - 35 | 2016 | Norm Perry Park | Recap |
| 2016-06-04 18:00:03June 4, 2016 | GTA All Stars @ Oakville Longhorns | 37 - 7 | 2016 | Bronte Athletic Field | Recap |
| 2016-06-04 18:00:31June 4, 2016 | Ottawa Invaders @ Steel City Patriots | 0 - 16 | 2016 | Mohawk Sports Complex | Recap |
| 2016-06-04 19:00:10June 4, 2016 |  Sarnia Imperials @ Sault Steelers | 17 - 0 | 2016 | Rocky DiPietro Field | Recap |
| 2016-06-04 19:30:26June 4, 2016 |  Tri-City Outlaws @ Sudbury Spartans | 14 - 21 | 2016 | James Jerome Sports Complex | Recap |
| 2016-06-11 18:00:06June 11, 2016 | Sudbury Spartans @ Oakville Longhorns | 21 - 26 | 2016 | Bronte Athletic Field | Recap |
| 2016-06-11 19:00:14June 11, 2016 | Sault Steelers @ Tri-City Outlaws | 13 - 14 | 2016 | Riverside Park Rogers Field | Recap |
| 2016-06-11 19:00:18June 11, 2016 | GTA All Stars @ Ottawa Invaders | 14 - 15 | 2016 | Gee-Gees Stadium | Recap |
| 2016-06-18 19:00:01June 18, 2016 | Ottawa Invaders @ Tri-City Outlaws | 25 - 9 | 2016 | Riverside Park Rogers Field | Recap |
| 2016-06-18 19:00:32June 18, 2016 | Sault Steelers @ Sarnia Imperials | 6 - 61 | 2016 | Norm Perry Park | Recap |
| 2016-06-18 19:00:39June 18, 2016 | Steel City Patriots @ GTA All Stars | 13 - 42 | 2016 | Chinguacousy Park | Recap |
| 2016-06-18 19:30:18June 18, 2016 | Oakville Longhorns @ Sudbury Spartans | 36 - 40 | 2016 | James Jerome Sports Complex | Recap |
| 2016-06-25 18:00:33June 25, 2016 | Oakville Longhorns @ Steel City Patriots | 6 - 28 | 2016 | Mohawk Sports Complex | Recap |
| 2016-06-25 19:00:40June 25, 2016 | Sudbury Spartans @ Ottawa Invaders | 3 - 24 | 2016 | Gee-Gees Stadium | Recap |
| 2016-06-25 19:00:41June 25, 2016 | GTA All Stars @ Sarnia Imperials | 75 - 17 | 2016 | Norm Perry Park | Recap |
| 2016-06-25 19:00:57June 25, 2016 | Tri-City Outlaws @ Sault Steelers | 30 - 6 | 2016 | Rocky DiPietro Field | Recap |
| 2016-07-02 18:00:14July 2, 2016 | Sudbury Spartans @ Steel City Patriots | 21 - 28 | 2016 | Mohawk Sports Complex | Recap |
| 2016-07-02 18:00:18July 2, 2016 | Sault Steelers @ Oakville Longhorns | 18 - 14 | 2016 | Bronte Athletic Field | Recap |
| 2016-07-02 19:00:11July 2, 2016 | Sarnia Imperials @ Tri-City Outlaws | 42 - 23 | 2016 | Riverside Park Rogers Field | Recap |
| 2016-07-09 19:00:40July 9, 2016 | Steel City Patriots @ Sarnia Imperials | 21 - 37 | 2016 | Norm Perry Park | Recap |
| 2016-07-09 19:00:51July 9, 2016 | Oakville Longhorns @ Ottawa Invaders | 8 - 31 | 2016 | Gee-Gees Stadium | Recap |
| 2016-07-16 18:00:38July 16, 2016 | Ottawa Invaders @ Oakville Longhorns | 57 - 0 | 2016 | Bronte Athletic Field | Recap |
| 2016-07-16 19:00:40July 16, 2016 | Sudbury Spartans @ Tri-City Outlaws | 24 - 28 | 2016 | Riverside Park Rogers Field | Recap |
| 2016-07-16 19:00:51July 16, 2016 | Steel City Patriots @ Sault Steelers | 28 - 21 | 2016 | Rocky DiPietro Field | Recap |
| 2016-07-16 19:30:19July 16, 2016 | Sarnia Imperials @ GTA All Stars | 35 - 28 | 2016 | Chinguacousy Park | Recap |
| 2016-07-23 18:00:06July 23, 2016 | Tri-City Outlaws @ Steel City Patriots | 21 - 14 | 2016 | Mohawk Sports Complex | Recap |
| 2016-07-23 19:30:06July 23, 2016 | Sault Steelers @ Sudbury Spartans | 8 - 33 | 2016 | James Jerome Sports Complex | Recap |
| 2016-07-23 19:30:08July 23, 2016 | Ottawa Invaders @ GTA All Stars | 10 - 21 | 2016 | Chinguacousy Park | Recap |
| 2016-07-30 19:00:44July 30, 2016 | GTA All Stars @ Sault Steelers | 49 - 20 | 2016 | Rocky DiPietro Field | Recap |
| 2016-07-30 19:30:27July 30, 2016 | Sarnia Imperials @ Sudbury Spartans | 49 - 10 | 2016 | James Jerome Sports Complex | Recap |
